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The genetic architecture of human brainstem structures and their involvement in common brain disorders
- Elvsashagen, T (author)
- Bahrami, S (author)
- van der Meer, D (author)
- show more...
- Alnaes, D (author)
- Barch, DM (author)
- Baur-Streubel, R (author)
- Bertolino, A (author)
- Beyer, MK (author)
- Blasi, G (author)
- Borgwardt, S (author)
- Boye, B (author)
- Buitelaar, J (author)
- Boen, E (author)
- Conzelmann, A (author)
- Coynel, D (author)
- Di Carlo, P (author)
- Djurovic, S (author)
- Eisenacher, S (author)
- Espeseth, T (author)
- Franke, B (author)
- Gelao, B (author)
- Harbo, HF (author)
- Hartman, CA (author)
- Haberg, A (author)
- Heslenfeld, D (author)
- Hoekstra, PJ (author)
- Hogestol, EA (author)
- Jonassen, R (author)
- Kirsch, P (author)
- Kloszewska, I (author)
- Lagerberg, TV (author)
- Landro, NI (author)
- Lesch, KP (author)
- Maglanoc, LA (author)
- Malt, UF (author)
- Mecocci, P (author)
- Melle, I (author)
- Meyer-Lindenberg, A (author)
- Moberget, T (author)
- Nordvik, JE (author)
- O'Connell, KS (author)
- Oosterlaan, J (author)
- Papalino, M (author)
- Papassotiropoulos, A (author)
- Pauli, P (author)
- Pergola, G (author)
- Persson, K (author)
- de Quervain, D (author)
- Reif, A (author)
- Rokicki, J (author)
- van Rooij, D (author)
- Shadrin, AA (author)
- Schmidt, A (author)
- Schwarz, E (author)
- Selbaek, G (author)
- Soininen, H (author)
- Sowa, P (author)
- Steen, VM (author)
- Tsolaki, M (author)
- Vellas, B (author)
- Wang, L (author)
- Ziegler, GC (author)
- Zink, M (author)
- Andreassen, OA (author)
- Westlye, LT (author)
- Kaufmann, T (author)
- Erhardt, SS (author)
- Collste, K (author)
- Victorsson, P (author)
- Hedberg, M (author)
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- (creator_code:org_t)
- 2020-08-11
- 2020
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4016-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
- Elvsashagen, T
- Bahrami, S
- van der Meer, D
- Agartz, I
- Alnaes, D
- Barch, DM
- show more...
- Baur-Streubel, R
- Bertolino, A
- Beyer, MK
- Blasi, G
- Borgwardt, S
- Boye, B
- Buitelaar, J
- Boen, E
- Celius, EG
- Cervenka, Simon
- Conzelmann, A
- Coynel, D
- Di Carlo, P
- Djurovic, S
- Eisenacher, S
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- Flyckt, L
- Franke, B
- Frei, O
- Gelao, B
- Harbo, HF
- Hartman, CA
- Haberg, A
- Heslenfeld, D
- Hoekstra, PJ
- Hogestol, EA
- Jonassen, R
- Jonsson, EG
- Kirsch, P
- Kloszewska, I
- Lagerberg, TV
- Landro, NI
- Le Hellard, S
- Lesch, KP
- Maglanoc, LA
- Malt, UF
- Mecocci, P
- Melle, I
- Meyer-Lindenberg ...
- Moberget, T
- Nordvik, JE
- Nyberg, Lars, 19 ...
- O'Connell, KS
- Oosterlaan, J
- Papalino, M
- Papassotiropoulo ...
- Pauli, P
- Pergola, G
- Persson, K
- de Quervain, D
- Reif, A
- Rokicki, J
- van Rooij, D
- Shadrin, AA
- Schmidt, A
- Schwarz, E
- Selbaek, G
- Soininen, H
- Sowa, P
- Steen, VM
- Tsolaki, M
- Vellas, B
- Wang, L
- Westman, E
- Ziegler, GC
- Zink, M
- Andreassen, OA
- Westlye, LT
- Kaufmann, T
- Farde, L
- Engberg, G
- Erhardt, SS
- Cervenka, S
- Schwieler, L
- Piehl, F
- Collste, K
- Victorsson, P
- Malmqvist, A
- Hedberg, M
- Orhan, F
- Sellgren, CM
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Psychiatry
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Radiology Nuclea ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
- Umeå University
- Uppsala University
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